A lion breaks loose in Seattle, leaving a couple’s lives and relationship at risk; Lexie overhears Mark’s discussion about moving in with Julia; Teddy begins to take steps towards coming to terms with Henry’s death; Callie grills Arizona on her past lovers; and Alex requests to be taken off Morgan’s preemie case when she becomes too dependent on him. Meanwhile, Meredith tries to be a support for Cristina as the tension between her and Owen hits a boiling point.

In order to convince Audrey he is making an effort in their relationship, Jeff sends her on a romantic scavenger hunt, with mixed results. Meanwhile, Adam leads Russell to believe that Jen has a sex tape.

A teenage heavy-metal fan in Baghdad shares a light moment with a U.S. soldier, who is forced to hide in the desert after her convoy is ambushed. Meanwhile, Martin encounters a man who knew his deceased wife; and a lottery winner meets a depressed pastor.

When The Machine spits out five numbers, naming the Don of each of New York’s crime families, Reese and Finch suspect Elias is planning to eliminate his competition.

An anthology of three horror stories presented by Geroge Romero. In "Quota," a pair of young lovers drive to Lovers' Leap, only to be attacked by a mysterious creature. In "Wet," a lonely man finds an empty box on the beach and opens it, with disastrous results. In "Valley of the Shadow," a woman searches for her missing husband in the jungles of South America, only to be in great danger herself.

With a dead body laying between them, two men wake up in the secure lair of a serial killer who's been nicknamed "Jigsaw". The men must follow various rules and objectives if they wish to survive and win the deadly game set for them.